How Influenza Spreads Within the Body

Insights into the acquisition of virulence of avian influenza viruses during a single passage in ferrets

J Butler, D Middleton, J Haining, R Layton, S Rockman, LE Brown, S Sapats

2019-10-04

Circulating avian influenza viruses pose a significant threat, with human infections occurring infrequently but with potentially s..

Inhibition of influenza a virus by human infant saliva

B Gilbertson, K Edenborough, J McVernon, LE Brown

2019-08-20

Innate antiviral factors in saliva play a role in protection against respiratory infections. We tested the anti-influenza virus ac..

Mouse saliva inhibits transit of influenza virus to the lower respiratory tract by efficiently blocking influenza virus neuraminidase activity

B Gilbertson, WC Ng, S Crawford, JL McKimm-Breschkin, LE Brown

2017-07-01

We previously identified a novel inhibitor of influenza virus in mouse saliva that halts the progression of susceptible viruses fr..

Salivary blockade protects the lower respiratory tract of mice from lethal influenza virus infection

K Ivinson, G Deliyannis, L McNabb, L Grollo, B Gilbertson, D Jackson, LE Brown

2017-07-01

It is possible to model the progression of influenza virus from the upper respiratory tract to the lower respiratory tract in the ..

Predicting disease severity and viral spread of h5n1 influenza virus in ferrets in the context of natural exposure routes

KM Edenborough, S Lowther, K Laurie, M Yamada, F Long, J Bingham, J Payne, J Harper, J Haining, R Arkinstall, B Gilbertson, D Middleton, LE Brown

2016-01-01

Although avian H5N1 influenza virus has yet to develop the capacity for human-to-human spread, the severity of the rare cases of h..

The source of the PB1 gene in influenza vaccine reassortants selectively alters the hemagglutinin content of the resulting seed virus

JCA Cobbin, EE Verity, BP Gilbertson, SP Rockman, LE Brown

2013-05-01

The yields of egg-grown influenza vaccines are maximized by the production of a seed strain using a reassortment of the seasonal i..

A mouse model for the study of contact-dependent transmission of influenza a virus and the factors that govern transmissibility

KM Edenborough, BP Gilbertson, LE Brown

2012-12-01

Influenza A virus transmission by direct contact is not well characterized. Here, we describe a mouse model for investigation of f..

Abortive replication of influenza virus in mouse dendritic cells

LJ Ioannidis, EE Verity, S Crawford, SP Rockman, LE Brown

2012-05-01

The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Here we show that infl..